availableAutomated aCRF Annotation Tool
aCRF Annotation
Automatically generates FDA/NMPA/EMA-compliant annotated CRFs (aCRFs) from blank CRF PDFs and SDTM mapping tables. Uses fuzzy matching to locate PDF fields, intelligently places SDTM domain/variable annotation boxes, and supports multi-domain splitting, conditional annotations, overlap detection, and auto-adjustment.
What it solves
Automatically generates FDA/NMPA/EMA-compliant annotated CRFs (aCRFs) from blank CRF PDFs and SDTM mapping tables. Uses fuzzy matching to locate PDF fields, intelligently places SDTM domain/variable annotation boxes, and supports multi-domain splitting, conditional annotations, overlap detection, and auto-adjustment.
Use Cases
aCRF annotation after SDTM standardization mappingClinical trial data submission (FDA/NMPA)Automatic CRF variable to SDTM domain correspondenceAnnotation quality QC and audit logging
Key Highlights
- Upload blank CRF PDF + SDTM mapping Excel, one-click aCRF generation
- 4-step fuzzy matching algorithm (exact → normalized → fuzzy → form context)
- Color-coded annotation boxes by SDTM domain, dashed borders for derived variables
- Automatic multi-domain row splitting, conditional annotation (when/then) parsing
- Overlap detection and smart position adjustment (up to 20 attempts)
- Complete processing log (match status, scores, page numbers, warnings)
Entry
Next Steps
Upload a blank CRF PDF and SDTM mapping Excel to generate an annotated aCRF online.